Space1 is genetically altering humans, hardened for the rigors of space flight. Most recently reported here:
https://space1usa.blogspot.tw/2018/02/space1-genetic-engineering-astronauts.html
The project has moved forward considerably. The trans-tech is now considering a focus on vision, hearing, feeling and the ability to sense G force and weightlessness.
The first genetically modded humans will most likely have the altercations of vision, hearing, and the ability to extract vibratory parameters as well as other senses, some of which may be empirically derived.